THE "ACTIVE INGREDIENTS" WE USE
This page will explain all the active ingredients that we use in
our anti-aging cosmetics
creams & serums.
We strive to use the most effective wrinkle reversal
ingredients
around.
ALL ABOUT HYALURONIC ACID


Hyaluronic Acid, or simply referred to as HA, occurs
naturally in the body. When we are born,the amount
of Hyaluronic Acid in our bodies is immense, but the
levels in the body decreases with each passing year.
HA
occurs naturally in the deeper layers of our skin
(the dermis). It helps to keep skin smooth and"plump"
through its ability to hold up to 1,000 times its weight
in water. Hyaluronic acid is what gives skin its volume
and fullness. As the levels of HA decrease in our bodies,
it adversely impacts the skin's ability to retain moisture.
Aging robs us of this innate ability to hold in moisture.
As we get
older our bodies produce less and less
hyaluronic acid. The drop in HA starts at around the
age of 18-20 years.
But after the age of 40 the down slide
becomes apparent. Skin starts to lose its elasticity and
lines and wrinkles
appear.
A popular natural molecule, Hyaluronic acid helps to store
water in the skin,providing essential
moisture to body pro-
cesses, contributing significantly to the skin maintaining a youthful appearance.
HA
helps control cell migration, which protect cells andalso activates white cells in the blood. With
its gaining popularity, the benefits of hyaluronic
acid in the skin care industry, is quickly becoming
one of the active anti-aging ingredients to look for in skin rejuvenation
products.

In skin rejuvenation, HA can be used topically or admin-
istered through
tiny injections under the skin which produces
similar skin plumping effects as collagen injections provide.
Plastic
Surgeons use Hyaluronic Acid as a wrinkle filler known as
Restylane, injecting it under the skin to
smooth out wrinkles.
Restylane is a gel of hyaluronic acid produced by bacteria and
used for treating facial wrinkles
and folds.The injections though
effective, are very expensive...not to mention painful!
Topically, the benefits of HA can be quite significant. Unlike topical
collagen
treat-ments, HA has the ability to be effectively absorbed
by the skin as well as serves as an efficient "carrier"
of other anti-
aging ingredients to cells. That means that the active anti-aging
ingredients are transported
to the cells through the layers of skin.
Hyaluronidase in the skin will break it down and the sugars released
will be used to make new hyaluronic acid
in our dermis.”
Topical Hyaluronic Acid
Topical
Hyaluronic Acid (HA) can help by increasing endogenous HA in the dermis and by attract-
ing a water layer on top of the
skin surface to protect against water loss. Bio-identical HA, topically
applied, can buffer the decreased production
of HA that occurs with age. Topical HA can serve as a
hydrating agent, rejuvenating skin and improving the tone and
appearance by enhancing the skin’s
ability to retain moisture. Applying a special HA serum that has a light, non-oily
texture, can soothe
skin, smooth fine lines and reduce the appearance of wrinkles. Pure HA is made with 100% pure, non-
animal based, bio-identical hyaluronic acid.
PEPTIDES
As we age, environmental factors, hormones, sun damage etc. cause our skin to
produce less collagen
and elastin. It is collagen that supports the structure of our skin making it firm and resilient.
The recent
development of Peptides (fragments of proteins) further enhance the ability to stimulate collagen,
allowing
us to offset many of the signs of aging. There are many types of Peptides.
| PEPTIDES |

|
Peptides and their Benefits:
Tetra and Pentapeptides-(favorites) stimulate
collagen to plump and firm the outermost layer of the skin.
Relax facial muscles that contribute to expression lines
and furrows.
Hexapeptides-Relax wrinkles to calm muscle contractions that contribute to our facial expressions that
result as deep furrows and wrinkles.
Tripeptide- (SynAke Trademark)-Also relaxes
facial muscles to offset facial expression linesand wrinkles.
Many refer to Peptides as “Botox without the Pain”. Peptides are a non invasive alternative by
which the
results are cumulative and continue to improve skin over time.
Matrixyl 3000
Matrixyl 3000, a palmitoyl pentapeptide pal-KTTKS, is a modified
chain of five amino acids developed
and patented as an antiaging active ingredient by the French company Sederma SA.
Matrixyl was
designed to promote collagen production in
the skin.
In a clinical trial, Matrixyl 3000 achieved the following results:
• 33% decrease in wrinkle density
• 23% decrease in
the volume of wrinkles
• 20% decrease in the depth of wrinkles
The benefits of Matrixyl are as effective as retinol without the
accompanying skin irritation, because
it does not energize inflammatory pathways as aggressively as retinol.
Matrixyl stimulates the "matrix" layers in the skin-- primarily collagen and fibronectin. When stimulated,
the skin produces more collagen. Loss of collagen is
what leads to thinning skin and the wrinkling of newly
inelastic skin. Matrixyl helps to counteract this natural part
of the aging process.
In clinical studies, Matrixyl was shown to:
- increase overall collagen synthesis by up to 117%
- increase collagen IV synthesis by up to 327%
- increase
hyaluronic acid synthesis by up to 267%
Deep wrinkles were reduced by half. Smaller wrinkles and fine lines sometimes faded completely away.
And
what's even better, every participant in the study showed noticeable improvement within two weeks.
The result was
fewer wrinkles and younger looking skin.

Argireline
Argireline® delivers superior anti-wrinkle results. Argireline is the trade name for Acetyl Hexapeptide-3,
a synthetic anti-aging cosmetic ingredient derived from natural proteins. It is a peptide; a chain made up
of
amino acids. It is a combination of amino acids formulated to relax facial wrinkles, reduce the degree of
existing wrinkles,
and stop their future development.This peptide complex works by
relaxing the muscles
rather than affecting the skin.
Cosmetics companies have marketed Argireline as a cheaper
alternative treatment to Botulinum Toxin A
(Botox), because the principles behind their chemical actions are similar.
Scientific studies suggest that as part of a low formulation in a cosmetic product Argireline
is a safe and
effective agent in skin care treatment.
Snap-8
The anti wrinkle octapeptide SNAP-8 is an elongation of the famous hexapeptide Argireline®. SNAP-8
reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression,
especially
in the forehead and around the eyes.
In clinical
studies, the severity of wrinkles around the eyes decreased up to 63.13%. Both in vivo and
in vitro efficacy testing
suggests that SNAP-8 is approximately 30% more active than its parent
peptide Argireline.
| COPPER PEPTIDES |

|
Copper Peptides
Copper Peptides triggers the skin's natural renewal mechanisms
to rebuild the protective barrier, increases
the skin's ability to hold water and aid in removing damaged cells.
Tests also show that it increases collagen
and elastin even more than Vitamin C. It induces the degradation of
"extra-large" collagen aggregates found
in scars and promotes the synthesis of smaller more regular collagen
found in normal skin.
Copper Peptides also promotes the synthesis of elastin, proteoglycans, glycosaminoglycans
and other com-
ponents of skin matrix. Other important effects of Copper Peptides include the ability to regulate the
growth
rate and migration of different types of cells; significant anti-inflammatory action; and the ability to prevent
the release of oxidation-promoting iron into the tissues.
LIPOSOMES

Liposomes are an important component of many skin rejuvenation
treatments because
of the ability of liposomes to encapsulate active anti-aging ingredients and deliver them
through the layers of skin right down to the cellular level
where they can do the most good.
This special delivery system
serves to provide cells with critical nutrients and the nourish-
ment necessary to promote collagen production.
Liposomes are nano-sized liposome particles resembling
biomembranes and have a very high affinity
for the skin. They can easily penetrate through the hard horny layer of theskin.
Based on this feature,
active ingredients can be incorporated into liposomes to enhance their absorption by the skin
and thus
their efficacy. In fact, liposome-encapsulation largely reduces the amount of the active ingredient
required
for effectivness as compared to non-encapsulated, pure active ingredients. Examples of such
encapsulated functional ingredients
include coenzyme Q10 and Ceramides.
Preliminary studies indicate that liposome skin treatments can be highly effective in rejuvenating aging
skin by improving skin hydration, reducing fine lines, diminish
wrinkles while improving skin texture.
Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic
substances into human skin.

In other words, Liposomes helps your skin absorb more readily and efficiently,
all the Anti Wrinkle ingredients
used in our Skin care Products!
As summarized in the Skin Rejuvenation Treatments e-Learning Module, the Fact Sheet on Anti-aging skin care
ingredients identifies liposome skin care
products as an anti-aging treatment that helps to improve skin by aiding
in repairing a variety of aging skin issues.
Ceramide 3
Ceramide 3 is a
variety of ceramidxes that restores the protective barrier function of the skin and enhances the
delivery and exchange
of skin lipids which results in enhanced moisturization and protection, leading to less
sensitive and dry skin.
The Ceramide 3 we use is encapulated in liposomes to enable skin poenetration & enhance its own synthesis of
ceramidesin
the skin by the linoleic acid of lipsomes. Its anti-aging & regenerating properties replenishes loss of
skin produced
ceramides & recovers barrier function, allowing the liposomes to penetrate into skin, preventing
water loss.
Cosmetic
Benefits of Ceramide 3:
Reinforces the natural lipid barrier of the skin, allowing deeper penetration of
hydration Improves long-term moisturization and protects the
skin from external influences. Repairs and protects damaged
hair (mechanical properties, liveliness, combability, shine). Human
skin identical molecule. Natural product with high purity.
Active at low concentrations.

Ceramide 3 [Efficacy Studies]
In this clinical study, Ceramide3 reduced deep wrinkles by as much as 68% over a period of six months.
Results may vary.
Hydration
of the Skin
Two Ceramide 3 formulations (0.05% and 0.5%), and a control product were applied on the forearms
of volunteers twice/day
for 7 consecutive days. During the application week Ceramide 3 resulted in a statis-
tically
significant increase in water retention capacity of the skin compared to the Control. A dose-response
effect with 0.05%
and 0.5% Ceramide3 was seen. After the application was ceased, areas treated with the
Control showed a rapid decrease
in hydration.
Transepidermal Water Loss
In
a second study, two Ceramide 3 formulations (0.2% and 0.5%), and a control product were applied on the
forearms of volunteers
twice/day for 7 consecutive days. After 7 days of application on healthy skin, no
disturbance of the normal skin physiology
was seen. Application of Ceramide 3 does not occlude the skin. After
irritation with SDS, untreated skin and areas treated
with the Control showed a lower increase in TEWL after SDS,
demonstrating the protective effect of Ceramide3 on the skin.

About DMAE, CoQ10, Alpha Lipoic Acid

|
| DMAE |
DMAE (Dimethylaminoethanol)
Also known as Deanol, DMAE enhances water retention in connective skin tissue, causing the surface of the
skin
to tighten. It sends signals from nerves to muscles may promote a form of muscle tightening in the skin.. The
molecule is an analog – a structural derivative – of one of the B vitamins. It is also a precursor of acetylcholine,
that is, it is one of the molecules used to build acetylcholine in cell metabolism. It is clinically proven to lift and
that lifts and firms the skin. Soothing, smoothing and strengthening of the cells.
One study (reported in the
American Journal of Clinical Dermatology in 2005) measured DMAE benefits by
comparing a group of volunteers using a topical
gel containing the molecule for 16 weeks, with a group who
used a gel that did not contain deanol. At the end of the
study, researchers found improvement in wrinkles in
the forehead, around the eyes and nose, and on the throat. The shape
and fullness of the lips also showed
improvement. When the volunteers stopped using the gel for two weeks, the skin did
not regress to its former
condition.
Recent studies involving
a gel formulation containing DMAE have shown that the compound can increase skin
firmness, even in younger subjects. Thirty healthy adults between the ages of 36 and 49 were given tests that
measured changes in skin tautness
after application with the DMAE gel, compared to placebo. Results indicated
that the placebo had little or no effect
on skin firmness, while the DMAE-treated skin exhibited greater tautness.

|
| CoQ10 MOLECULE |
CoQ10(Coenzyme Q10)
CoQ10 is an antioxidant that appears in almost every cell in the body and helps to fight against free radicals.
The benefits of CoQ10 are plentiful, especially since it is naturally found in the energy-producing cells of the heart.
CoQ10 quickly reduces the appearance of wrinkles, age spots and many signs of aging, such as; fine lines, puffy
eyes and dark circles. Studies have shown that CoQ10 may help increase collagen and elastin in the skin, and help
repair damaged skin cells.
CoQ10 may be more effective than other topical vitamin treatments because it is a
small molecule that can
relatively easily penetrate into skin cells.
| ALPHA LIPOIC ACID |

|
Alpha Lipoic Acid
Alpha-lipoic
acid (ALA), also known as Lipoic Acid (or Thioctic Acid), is a potent biological antioxidant that has
been shown to slow
the oxidative damage in cells, and in many cases stabilize or even reverse cell damage,
keeping skin healthy and youthful
in appearance. A sulfur-containing fatty acid found inside every cell of the
human body, its main function is to generate
the energy required to keep living organisms alive and functioning.
Alpha-lipoic acid is so effective as an anti-oxidant
because it works on both water and fat-soluble free radicals
that cause oxidation and cell damage in the body.
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